Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil
نویسندگان
چکیده
منابع مشابه
Organic–Inorganic Hierarchical Self-Assembly into Robust Luminescent Supramolecular Hydrogel
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 1 wileyonlinelibrary.com through the excitation of OH vibrations.[5] On the other hand, the mechanical properties of supramolecular gels typically suffer from the relatively weak noncovalent interactions among the constituent components.[6] This drawback also limits construction of free-standing objects from the luminescent gels.[7] Herein for ...
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Hydrogels formed by ultrashort peptides are emerging as cost-effective materials for cell culture. However, L-peptides are labile to proteases, while their D-isomers are thought to not support cell growth as well. In contrast, the self-assembly behaviour and biological performance of heterochiral peptides (i.e., made of both d and l amino acids) are largely unknown. In this study, we evaluate t...
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Methylglyoxal (MGO) is a toxic, dicarbonyl metabolite in all living cells and its detoxification is regulated by glyoxalase I (GLOI). Herein, we rationally designed a precursor o-phenylenediamine-Phe-Phe-OH (1) which “click” reacts with MGO to yield amphiphilic methylquinoxaline-Phe-Phe-OH (2) to self-assemble into supramolecular hydrogel II (Gel II). Cryo-TEM images of Gel II suggested that th...
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ژورنال
عنوان ژورنال: Gels
سال: 2019
ISSN: 2310-2861
DOI: 10.3390/gels5010005